Feedback loops have been identified in a variety of regulatory systems and organisms. While feedback loops of the same type (negative or positive) tend to have properties in common, they can play distinctively diverse roles in different regulatory systems, where they can affect virulence in a pathogenic bacterium, maturation patterns of vertebrate oocytes and transitions through cell cycle phases in eukaryotic cells. This review focuses on the properties and functions of positive feedback in biological systems, including bistability, hysteresis and activation (...) surges. BioEssays 30:542–555, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

The origin of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the subject of many hypotheses. One of them, proposed by Segreto and Deigin, assumes artificial chimeric construction of SARS‐CoV‐2 from a backbone of RaTG13‐like CoV and receptor binding domain (RBD) of a pangolin MP789‐like CoV, followed by serial cell or animal passage. Here we show that this hypothesis relies on incorrect or weak assumptions, and does not agree with the results of comparative genomics analysis. The genetic divergence between SARS‐CoV‐2 (...) and both its proposed ancestors is too high to have accumulated in a lab, given the timeframe of several years. Furthermore, comparative analysis of S‐protein gene sequences suggests that the RBD of SARS‐CoV‐2 probably represents an ancestral non‐recombinant variant. These and other arguments significantly weaken the hypothesis of a laboratory origin for SARS‐CoV‐2, while the hypothesis of a natural origin is consistent with all available genetic and experimental data. (shrink)

States are rapidly modifying law and policy to increase access to the opioid antidote naloxone, and the provision of naloxone rescue kits for use in the event of overdose is becoming increasingly common. As of late 2014 the majority of states had passed laws increasing naloxone access, and nearly as many have modified emergency responder scope of practice protocols to permit Emergency Medical Technicians and law enforcement officers to administer the medication. While the text of these laws is generally similar, (...) their implementation varies among states.This article outlines experiences and lessons learned from two diverse states, Massachusetts and North Carolina. In Massachusetts naloxone access initiatives were well underway before formal legislative action occurred, while in North Carolina the passage of a naloxone access law served as a catalyst for the creation of new programs and facilitated the scale-up of existing ones. In both states legislative action was necessary to permit the prescription and dispensing of naloxone to the friends and family members of people who use opioids, a key legal change. (shrink)

The causative agent of COVID‐19 SARS‐CoV‐2 has led to over 4 million deaths worldwide. Understanding the origin of this coronavirus is important for the prevention of future outbreaks. The dominant point of view that the virus transferred to humans either directly from bats or through an intermediate mammalian host has been challenged by Segreto and Deigin, who claim that the genome of SARS‐CoV‐2 has certain features suggestive of its artificial creation. Following their response to our commentary, here we continue the (...) discussion of the proposed arguments for this hypothesis. We show that neither the existence of a furin cleavage site in SARS‐CoV‐2, nor the presence of specific sequences within the nucleotide insertion encoding that site are evidence for intelligent design. We also explain why existing genetic data, viral diversity and past human history suggest that a natural origin of the virus is the most likely scenario. Genetic evidence suggesting otherwise is yet to be presented. (shrink)

Explaining how stereotypes and norms influence role-identities during reflected appraisal processes, we develop a theory about diverse groups of minority men—the “minority masculinity stress theory”—and apply it to Asian American men. We conceptually integrate hegemonic masculinity, stereotypes, and mental health to examine how Asian American men experience masculinity and how their experiences are uniquely stressful. We analyze elicited text from an open-ended questionnaire to explain two experiences of masculinity-related stress: trying to live up to the masculine ideal and enacting work-related (...) role-identities. Regarding the former, we discuss four illustrations—toughness, body image, restrictive emotionality, and heterosexuality—and two involving the latter—achiever and provider. We found that Asian American men receive stereotypical reflected appraisals that contradict potentially positive self-concepts and emphasize achievement beyond typical standards of hegemonic masculinity. Moreover, Asian American men’s role-identities contradict hegemonic masculinity, resulting in reflected appraisals that predispose them toward stress. (shrink)

Most jurisdictions require that a mental capacity assessment be conducted using a functional model whose definition includes several abilities. In England and Wales and in increasing number of countries, the law requires a person be able to understand, to retain, to use or weigh relevant information and to communicate one’s decision. But interpreting and applying broad and vague criteria, such as the ability ‘to use or weigh’ to a diverse range of presentations is challenging. By examining actual court judgements of (...) capacity, we previously developed a descriptive typology of justifications used in the application of the Mental Capacity Act criteria. We here critically optimise this typology by showing how clear definitions—and thus boundaries—between the criteria can be achieved if the ‘understanding’ criterion is used narrowly and the multiple rationales that fall under the ability to ‘use or weigh’ are specifically enumerated in practice. Such a typology-aided practice, in theory, could make functional capacity assessments more transparent, accountable, reliable and valid. It may also help to create targeted supports for decision making by the vulnerable. We also discuss how the typology could evolve legally and scientifically, and how it lays the groundwork for clinical research on the abilities enumerated by the MCA. No data are available. This paper does not report any original data. (shrink)

Contemporary bioethics education has been developed predominately within Euro-American contexts, and now, other global regions are increasingly joining the field, leading to a richer global understanding. Nevertheless, many standard bioethics curriculum materials retain a narrow geographic focus. The purpose of this article is to use local cases from the Asia-Pacific region as examples for exploring questions such as ‘what makes a case or example truly local, and why?’, ‘what topics have we found to be best explained through local cases or (...) examples?’, and ‘how does one identify a relevant local case?’ Furthermore, we consider the global application of local cases to help extend the possible scope of the discussion, opening new avenues for the development of practical bioethics educational materials. We begin with a background description and discussion of why local cases enhance bioethics education, move to an overview of what is currently available and what is not for the region, and then outline a discussion of what it means to be local using example cases drawn from Hong Kong, Australia, Pakistan, and Malaysia. We are not creating a casebook but rather constructing by example a toolbox for designing active and dynamic learning cases using regional diversity as contextualised cases with generalised principles. (shrink)

Perceptual conscious experiences result from non-conscious processes that precede them. We document a new characteristic of the cognitive system: the speed with which visual meaningful stimuli are prioritized to consciousness over competing noise in visual masking paradigms. In ten experiments (N = 399) we find that an individual's non-conscious visual prioritization speed (NVPS) is ubiquitous across a wide variety of stimuli, and generalizes across visual masks, suppression tasks, and time. We also find that variation in NVPS is unique, in that (...) it cannot be explained by variation in general speed, perceptual decision thresholds, short-term visual memory, or three networks of attention (alerting, orienting and executive). Finally, we find that NVPS is correlated with subjective measures of sensitivity, as they are measured by the Highly Sensitive Person scale. We conclude by discussing the implications of variance in NVPS for understanding individual variance in behavior and the neural substrates of consciousness. (shrink)

The modern legal and ethical movement against traditional welfare paternalism in medical decision-making extends to how decisions are made for patients lacking decisional capacity, prioritising surrogates’ judgment about what patients would have decided over even their best interests. In England and Wales, the Mental Capacity Act 2005 follows this trend of prioritising the patient’s prior wishes, values and beliefs but the dominant interpretation in life-sustaining treatment cases does so by in effect calling those values the ‘best interests’ of the patient (...) and focusing nearly exclusively on the ‘subjective’ viewpoint of the patient. In this article, we examine the recent Court of Protection judgment inBarnsley Hospitals NHS Foundation Trust v MSP[2020] EWCOP 26, which adhered closely to this approach, to suggest that it could have unexpected negative consequences. These include insufficient information gathering about and attention to patients’ objective medical interests, inadequacy of the evidentiary standard used for the substituted decision-making and, in some cases, even prioritising a surrogate’s current substituted judgment over the potential for an actual judgment by the patient. (shrink)

Reorienting the Political examines the reception of two controversial German philosophers, Carl Schmitt and Leo Strauss, in the Chinese-speaking world. This volume explores the powerful resonance of both thinkers in Chinese political thought from a cross-cultural and interdisciplinary perspective.

The COVID-19 pandemic put a large burden on many healthcare systems, causing fears about resource scarcity and triage. Several COVID-19 guidelines included age as an explicit factor and practices of both triage and ‘anticipatory triage’ likely limited access to hospital care for elderly patients, especially those in care homes. To ensure the legitimacy of triage guidelines, which affect the public, it is important to engage the public’s moral intuitions. Our study aimed to explore general public views in the UK on (...) the role of age, and related factors like frailty and quality of life, in triage during the COVID-19 pandemic. We held online deliberative workshops with members of the general public. Participants were guided through a deliberative process to maximise eliciting informed and considered preferences. Participants generally accepted the need for triage but strongly rejected ‘fair innings’ and ‘life projects’ principles as justifications for age-based allocation. They were also wary of the ‘maximise life-years’ principle, preferring to maximise the number of lives rather than life years saved. Although they did not arrive at a unified recommendation of one principle, a concern for three core principles and values eventually emerged: equality, efficiency and vulnerability. While these remain difficult to fully respect at once, they captured a considered, multifaceted consensus: utilitarian considerations of efficiency should be tempered with a concern for equality and vulnerability. This ‘triad’ of ethical principles may be a useful structure to guide ethical deliberation as societies negotiate the conflicting ethical demands of triage. (shrink)

All contemporary frameworks of mental capacity stipulate that we must begin from the presumption that an adult has capacity. This presumption is crucial, as it manifests respect for autonomy and guards against prejudice and paternalism on the part of the evaluator.Given its ubiquity, we might presume that we all understand the presumption’s meaning and application in the same way. Evidence demonstrates that this is not the case and that this has led to harm in vulnerable persons. There is thus strong (...) reason to question our presumptions about the presumption of capacity.We distinguish between two main ways of understanding and applying the presumption of capacity, and advocate for the one that we argue mitigates risk of harm. Our proposed interpretation offers many advantages in that it is consonant with actual practice of capacity evaluations, precludes confused and abusive avoidance of needed evaluations, and preserves the respect for autonomy motivating the presumption in the first place. (shrink)

According to James Woodward’s influential interventionist account of causation, X is a cause of Y iff, roughly, there is a possible intervention on X that changes Y. Woodward requires that interventions be merely logically possible. I will argue for two claims against this modal character of interventions: First, merely logically possible interventions are dispensable for the semantic project of providing an account of the meaning of causal statements. If interventions are indeed dispensable, the interventionist theory collapses into a counterfactual theory (...) of causation. Thus, the interventionist theory is not tenable as a theory of causation in its own right. Second, if one maintains that merely logically possible interventions are indispensable, then interventions with this modal character lead to the fatal result that interventionist counterfactuals are evaluated inadequately. Consequently, interventionists offer an inadequate theory of causation. I suggest that if we are concerned with explicating causal concepts and stating the truth-conditions of causal claims we best get rid of Woodwardian interventions. (shrink)

Este artículo pretende generar claridades sobre el planteamiento sistémico, llevado a los universos de la escuela y la familia. Se plantean lugares de encuentro entre estos dos sistemas interconexionados por el pensamiento sistémico y la comunicación, rescatando que la escuela y la familia han sido determinantes en la configuración de subjetividades y sociedades. Estas reflexiones permiten concluir que las manifestaciones recíprocas de la familia y la escuela esculpen maneras de ser y de estar en el mundo.

La compasión es una actitud que ha sido objeto de ataques, que ha sido catalogada como un egoísmo encubierto o bien como una pose lastimera que poco o nada contribuye para el auxilio debido a las personas en desgracia. Pero, es precisamente el despojo y los daños que las personas sufren los que llevan a pensar cómo es posible «salvar» esas vidas, no permitir que se pierdan y afirmar que la vida vale la pena. En virtud de ello, la compasión (...) o misericordia ha de ser repensada con miras a concederle el lugar adecuado dentro del mundo sanitario. Su significado ético pasa, por tanto, por una elucidación racional –qué es- y los rasgos que la caracterizan –fragilidad, desgracia, reconocimiento, solidaridad-. El símbolo da que pensar, y la reflexión ética, en este caso, se nutre de la parábola del Buen Samaritano. (shrink)

Fregeans follow Frege in accepting informativeness and substitution failure as reliable criteria for the existence of senses as objects of thought. In this paper I show that if we accept this, we must also accept the existence of an infinite hierarchy of senses as objects of thought. This is a bad result since it turns Fregeanism into a doctrine according to which object-related thoughts either have an infinite number of objects as contents or none at all. This shows, against the (...) Fregean, that senses cannot themselves be constituents of thought. Los fregeanos aceptan, siguiendo a Frege, que los criterios de informatividad y falla de sustitución son guías confiables de la existencia de sentidos como objetos del pensamiento. En este artículo muestro que si aceptamos esta tesis también debemos aceptar la existencia de una jerarquía infinita de sentidos como objetos del pensamiento. Esta es una mala consecuencia pues convierte al fregeanismo en una doctrina según la cual los pensamientos dirigidos a objetos o bien tienen un número infinito de objetos como contenido o ninguno. Esto muestra, contra los fregeanos, que los sentidos no pueden ellos mismos ser objeto del pensamiento. (shrink)

Hasdai Crescas (1340-1411) fue un filósofo, rabino y figura pública que vivió en un período muy turbulento para las comunidades judías ibéricas y provenzales de la Baja Edad Media. Crescas lanzó una crítica vehemente contra el paradigma aristotélico recibido de la _falsafa_, que fue utilizado por Maimónides para sustentar y probar la existencia, unidad e incorporeidad de Dios, conceptualizado en la _Guía de los perplejos_ como el ser necesario absolutamente trascendente en relación con el ser contingente, es decir, el mundo. (...) En _Or Hashem_, Crescas elabora un concepto alternativo del ser necesario, en el que las dos nociones antitéticas de inmanencia y trascendencia divinas se relacionan con la distinción en el ser necesario entre su esencia simple y sus atributos infinitos. La esencia simple, una e inefable del ser necesario, se expresa en infinitos atributos en el acto eterno y constante de otorgar en la univocidad del ser su bondad y su actualidad a los infinitos seres contingentes. Crescas defiende que el universo, aunque ontológicamente contingente, es infinito en su actualidad. Dios es así concebido como la primera causa, eterna y constante, entelequia y “Lugar del Mundo”. (shrink)

Executive function is essential to child development, with associated skills beginning to emerge in the first few years of life and continuing to develop into adolescence and adulthood. The prefrontal cortex, which follows a neurodevelopmental timeline similar to EF, plays an important role in the development of EF. However, limited research has examined prefrontal function in young children due to limitations of currently available neuroimaging techniques such as functional resonance magnetic imaging. The current study developed and applied a multimodal Go/NoGo (...) task to examine the EF component of inhibitory control in children 4–10 years of age. Cortical activity was measured using a non-invasive and child-friendly neuroimaging technique – functional near-infrared spectroscopy. Children’s response accuracy and reaction times were captured during the fNIRS session and compared with responses obtained using the standardized assessments from NIH Toolbox cognition battery. Results showed significant correlations between the behavioral measures during the fNIRS session and the standardized EF assessments, in line with our expectations. Results from fNIRS measures demonstrated a significant, age-independent effect of inhibitory control in the right PFC, and an age-dependent effect in the left orbitofrontal cortex, consistent with results in previous studies using fNIRS and fMRI. Thus, the new task designed for fNIRS was suitable for examining IC in young children, and results showed that fNIRS measures can reveal prefrontal IC function. (shrink)

El presente estudio busca clarificar el papel de la phantasia en la refundacion de la fenomenologia transcendental de Marc Richir (en particular desde Phenomenologie en esquisses, de 2000). A partir del analisis de la phantasia y de la imaginacion ��que toma apoyo en las Lecciones de Husserl de 1904/1905�� el autor pone de manifiesto la relacion de la phantasia tanto con la percepcion como con el lenguaje, al tiempo que trata de elucidar el estatuto temporal de dichos elementos.

El proceso de enseñanza-aprendizaje de la Historia de Cuba adquiere singular relevancia en la carrera Ingeniería de Minas, esta tiene como graduar un ingeniero minero de perfil amplio, que esté capacitado científica y técnicamente para ejecutar trabajos de explotación racional de los recursos minerales. Los cambios son muy rápidos y la educación debe facilitar la adaptación de los alumnos a los mismos. Para ello, la utilización de un entorno virtual de aprendizaje o EVA puede ser una herramienta de gran utilidad.

This paper raises the question – based on the works of Marc Richir and Dominique Pradelle – if and how phenomenology deals with an “anti-Copernican” revolution, considering that the motif of a “Copernican” revolution seems to have gone through some modifications that reflect a certain deposition of the constitutive role of the subject. Its fundamental thesis is that a certain dimension “beyond” the Copernican revolution does not reestablish a “Ptolemaic” realism but rather opens a dimension “beneath”: beneath the subject and (...) the object where can take place a mutual relationship between an a-subjective constitutive power and a pre-empirical foundational being. This dimension “beneath” means that the alternative does not concern a “pre-Copernican” realism on the one hand and an “idealism” leaving in the shadows the relationship between the transcendental method and an ontological perspective on the other, but rather puts forward a constructive circularity between the transcendental constitution and an ontological foundation. It follows that “normativity” is not achieved on the basis of pre-given objectivity – because it would mean a petition principia – but draws upon the “pre-immanent generativity”. (shrink)

El presente artículo examina el concepto de necesidad causal y de contingencia en Roberto Kilwardby (ca. 1215-1279).Este autor, en su Comentario a los Segundos Analíticos de Aristóteles y en el De ortu scientiarum, parece particularmente interesado en el precario estatuto epistemológico de la ética y de la física en tanto que estas disciplinas versan sobre acontecimientos contingentes. Con el fin de reconciliar el conocimiento científico en sentido estricto con formas conjeturales de conocimiento, Kilwardby sitúa el problema de la contingencia en (...) un contexto auténticamente gnoseológico, más que metafísico, llegando así a una explicación altamente original de la contingencia. (shrink)

En el siglo que venimos de cerrar, el problema de la relación entre fe y razón ha encontrado una de sus respuestas mas sugerentes con la reconciliación de sobre naturaleza y naturaleza propuesta por la llamada "Nouvelle Théologie" y llevada a cabo por Karl Rahner y su enfoque "transcendental?antropológico". Sin embargo, esta respuesta no carece de antecedentes en la historia de la Teología y la Filosofía como lo demuestra el interesante caso de Ramón Sibiuda quien, con su Liber creaturarun redactado (...) hacia el 1436, propone precisamente una Antropología Filosófica como acceso privilegiado a la Teología y sus misterios de fe. El presente estudio esclarece las líneas generales de la argumentación de Sibiuda subrayando la actualidad de sus conceptos clave, como lo son la experiencia y el deseo natural hacia Dios. (shrink)

Los estudiosos que se han ocupado durante el último siglo de la transmisión del saber en la obra de Gundisalvo, han prestado mucha -por no decir exclusiva- atención a su recepción e integración de elementos arábigo-judíos. Sin embargo, para entender adecuadamente este proceso de integración parece imprescindible analizar también la recepción de la tradición latino-cristiana en la obra del arcediano, ya que ésta condiciona dicho proceso. Partiendo de la recepción de la metodología de las ciencias según Boecio por Gundisalvo, el (...) presente estudio pretende demostrar cómo los problemas que Gundisalvo encontró en su propia tradición influyen en su recepción y traducción de la filosofía arábigo-judía. (shrink)